2025-08-28
P-values from LEGEND study show natural distribution without publication bias
Suspicious cutoff at p = 0.05 indicates selective reporting
| Diagnostic | Threshold | Purpose |
|---|---|---|
| Covariate Balance (SMD) | < 0.1 | Ensure treatment groups are comparable |
| Empirical Equipoise | > 0.1 | Confirm clinical uncertainty exists |
| Systematic Error (EASE) | < 0.25 | Don’t report biased results |
| Minimum Detectable Risk | < 10 | Ensure adequate statistical power |
Semaglutide-NAION Analysis
Pass Example (IQVIA Claims)
Fail Example (JHMI EHR)
| Diagnostic | Threshold | Purpose |
|---|---|---|
| Pre-exposure | > 0.05 | Check for outcome-exposure dependence |
| Time Trend | > 0.05 | Account for temporal patterns |
| Systematic Error (EASE) | < 0.25 | Limit acceptable bias level |
| Minimum Detectable Risk | < 10 | Ensure adequate statistical power |
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